Erythromycin ointment is useful for mild anal fissures. In addition, general treatment, medication such as vasodilators, and surgery can be performed in severe cases. If the anal fissure is mild and bleeding is not obvious, erythromycin can be used for treatment. However, if the anal fissure is more serious, the use of erythromycin alone is not effective. Anal fissure can be general treatment, such as after defecation can use 1:5000 potassium permanganate warm water sitz bath, keep local clean. Other drugs can also be used for treatment, for patients with obvious pain can use local analgesic drugs such as lidocaine gel paste, etc., can also be used locally vasodilator such as nitroglycerin. Serious anal fissure requires surgical treatment including anal fissure resection. If the phenomenon of anal fissure, go to the hospital in time for treatment, the use of the above drugs need to follow the doctor’s instructions.