Definition: The disease is an inherited disorder characterized by left and right ventricular hypertrophy. Pathological manifestations of myocardial examination are hypertrophy of cardiac myocytes, disorganized arrangement and the presence of fibrosis between cells. Myocardial hypertrophy is mostly asymmetric, with septal hypertrophy being the most common, and hypertrophy can also occur in the mid-ventricular and apical regions of the heart. The disease causes left ventricular outflow tract obstruction and often causes mitral valve antegrade, leading to mitral regurgitation and worsening the obstruction. The incidence in the general population is 0,2%. Symptoms: Patients with this disease may experience angina pectoris, shortness of breath after activity, syncope, and vertigo. Patients with atrial fibrillation may also have palpitations, and half of them may develop systemic embolism. Other rhythm disturbances include premature ventricular contractions, ventricular tachycardia, supraventricular tachycardia, and in severe cases, sudden death. In the late stage, patients may have paroxysmal dyspnea, seated breathing and pulmonary edema. In the presence of severe tricuspid regurgitation, patients may develop ascites and lower limb edema. Treatment: I. Non-surgical treatment Betablockers The commonly used drug is betalactone, which can reduce left ventricular outflow tract obstruction, lower heart rate, improve ventricular filling, and reduce cardiac oxygen consumption. Calcium channel blockers Commonly used is verapamil, which reduces LV outflow tract obstruction, improves symptoms and mobility, but has arrhythmogenic effects. Biventricular pacing is less effective in reducing left ventricular outflow tract obstruction and is less commonly used. Anhydrous alcohol septal ablation can reduce left ventricular outflow tract obstruction and reduce left heart outflow tract obstruction, but the scar tissue formed by ablation can cause arrhythmias and has a 2% mortality rate. Surgery can completely relieve the left ventricular outflow tract obstruction, and the risk of surgery is low, which can significantly reduce the risk of sudden death and is by far the most effective treatment. (1) Obvious symptoms, cardiac function grade 3 or above, ineffective medical treatment, left ventricular outflow tract pressure difference of more than 50 mmHg, mitral valve systolic antegrade, moderate mitral regurgitation or above. (2) The symptoms are not obvious, but the left ventricular outflow tract obstruction is severe, combined with severe mitral regurgitation, and there is new-onset atrial fibrillation. (3) Left ventricular outflow tract obstruction, history of syncope, history of unexplained cardiac arrest. 2.Surgical methods Surgical methods include partial septal muscle resection, mitral valvuloplasty, mitral valve replacement, apical-aortic band valve conduit, heart transplantation, etc., which are used according to different conditions.