Early signs of uremia men and women generally no significant difference, are mainly anemia, foamy urine, edema, limb weakness and other signs. 1. anemia: anemia is one of the early symptoms of uremia, patients suffering from uremia, kidney function regression, glomerular filtration function is reduced, resulting in the body of metabolic waste excretion difficulties, bone marrow hematopoietic abnormalities, coagulation dysfunction resulting in bleeding disorders, erythropoietin generation is reduced, resulting in the emergence of anemia symptoms. 2. Foamy urine: some patients with early uremia, due to renal damage caused by renal protein leakage, resulting in the formation of proteinuria, also known as foamy urine. In addition, uremia patients also have symptoms of increased nocturia. 3. Edema: In some patients with early uremia, kidney dysfunction leads to water not being able to be excreted, resulting in water retention, which will be manifested as edema. Edema is usually the earliest facial edema, and in the late stage, it can be combined with pleural effusion, peritoneal effusion, pericardial effusion and even peripheral swelling. 4. Weakness of the limbs: early uremia will also appear the phenomenon of weakness of the limbs. After the patient’s illness, renal function is reduced, the body electrolyte disorders, the digestive system will also appear nausea, vomiting and other symptoms, which will lead to the patient’s limbs weak, poor spirit and so on. There are many other symptoms of uremia, such as itchy skin, insomnia, restless legs and so on. It is recommended that patients with uremia go to a regular hospital in a timely manner, complete the relevant examinations, and follow the doctor’s instructions for standardized treatment.