Vulvovaginal neurodermatitis is treated with general measures and medication. 1. General measures: vulvovaginal neurodermatitis is a common gynecological clinical skin neurological dysfunction disease, usually due to patients do not pay attention to vulvar hygiene, resulting in sweat, vaginal secretions and other long-term stimulation of vulvar skin. Therefore, patients usually pay attention to the vulva cleaning, regular change of underwear, wash the vulvar skin with warm water every day. Secondly, patients should avoid using irritating vulvar lotion or soap when washing the vulva, to avoid aggravating the symptoms. In addition, they should pay attention to relax and avoid anxiety. 2. Drug therapy: drug therapy is one of the main treatment means of the disease, patients can follow the doctor’s instructions to use tretinoin ointment and other glucocorticoid topical drugs, or fluoride ointment and other adrenocorticotropic hormone topical drugs to alleviate clinical symptoms. If the patient’s condition is more serious, the skin has appeared mossy, can be combined with the use of 5% salicylic acid ointment and other drugs. It is recommended that patients with vulvar neurodermatitis seek medical treatment as soon as possible, and pay attention to daily care after treatment to reduce the chance of recurrence.