The principles of herpes simplex treatment are to shorten the course of the disease, prevent secondary bacterial infection and systemic dissemination, and reduce the chance of recurrence and transmission. Treatment is as follows: 1. Antiviral therapy: Antiviral therapy is divided into: primary herpes simplex, antiviral therapy for severe or potentially severe primary herpes simplex virus infection, either acyclovir 200mg per dose, 5 times daily or 400mg per dose, 3 times daily orally, or valacyclovir 500mg per dose, 2 times daily orally, or famciclovir 250mg per dose, 3 times daily. Treatment of recurrent herpes simplex is best started within 24 hours of the onset of symptoms or lesions with acyclovir 200mg 5 times daily or 400mg 3 times daily orally, or famciclovir 500mg 1-2 times daily or famciclovir 125mg twice daily. Frequent relapses are generally defined as more than 6 relapses a year and can be treated with daily suppressive therapy to reduce the number of relapses and acyclovir 400mg orally 3 times daily or valacyclovir 500mg orally 1-2 times daily or famciclovir 250mg orally 2 times daily for 6-12 months; severe symptoms of primary infection or lesions, rash extensive, acyclovir 5-10mg/(kg-d), divided into 3 times through the intravenous drip, the course of treatment is generally 5-7 days, the use of this drug pay attention to slow intravenous drip, while appropriate hydration, renal insufficiency patients need to adjust the dose according to renal function; severe herpes simplex to acyclovir-resistant people can consider the use of sodium phosphatidylate treatment; 2, topical drug treatment: to astringent dry and To prevent recurrence and secondary occurrence, 3% of acyclovir ointment, 1% of penciclovir ointment or sulfur glycolic lotion can be used, and 0.5% of neomycin cream and mupirocin ointment can be used for those with secondary infection. For patients with herpetic gingivitis, the mouth should be kept clean and taken with 1:1000 benzalkonium bromide solution.