Small blisters on the hands (i.e., “blisters”) are commonly associated with herpes, eczema, or ringworm. Drugs should be chosen according to different causes. Commonly used clinical drugs include tretinoin urea cream, mometasone furoate cream, amorolfine hydrochloride cream, etc. 1. Sweat herpes: it is a blistering dermatosis that occurs symmetrically on the hands and/or feet, often manifested as small blisters deep in the epidermis. First of all, the affected area should be kept dry, can be used externally with glycerine lotion, etc. After the blisters dry up, glucocorticoid drugs can be used, such as tretinoin urea cream. 2. Eczema: it is an inflammatory disease of the superficial dermis and epidermis caused by many factors inside and outside, often manifested as blisters with itching on the hands. Patients can use glucocorticoid creams for treatment, commonly used drugs such as mometasone furoate cream and Dinaid cream. If the patient’s itching symptoms are serious, then with the use of anti-allergic anti-itching drugs, such as loratadine and so on. 3. Ringworm: a disease caused by fungal infection, can appear red spots, papules, blisters, itching and other symptoms. When the lesions are oozing, it is necessary to use boric acid solution to apply wet compresses first, and then use antifungal drugs externally after drying, such as biphenylbenzylazole cream, amorphophine hydrochloride cream, etc.; if the lesions are not oozing, it is possible to use antifungal infections externally to treat the drug, and if necessary, it is necessary to follow the doctor’s instructions to take oral antifungal medicines. The symptoms of blisters on the hands can also be seen in other causes, it is recommended to go to the hospital, clear cause of the disease and follow the doctor’s prescription medication.