I. Altered thinking, emotion, and behavior but with self-awareness: 1. Perceptual hypersensitivity: abnormal visual, auditory, tactile, and interpersonal distance perception; 2. Thinking disorders: loss of reality, depersonalization, exaggerated ideas, and logical naivete; 3. Abnormal perceptual experiences: “ghosts”, imaginary friends, hallucinations, and strange sounds; 4. Fear: avoidance of physical harm, fear of being attacked (social phobia); 5. Disorganized and irrelevant speech: no theme in expression; 6. Absurd and anachronistic behavior: preoccupied concepts, purposeless behavior, eccentric appearance; 7. Diminished emotional and social responses: depression, reticence, low energy, mild dementia. Significantly reduced functioning: 1. unexplained reduction in work and learning ability; 2. reduced attention and motivation; 3. reduced ability to handle personal hygiene; 4. reduced ability to cope with life events and stress. Alienation from family and friends: 1. Loss of interest in friends, amateur sports or hobbies; 2. Increased alienation and self-isolation; 3. Family alienation, resentment, increased hostility, and paranoia.