The hand is rubbed blisters, may be the hand long-term friction or extrusion caused by, if the blisters are small, generally do not need special treatment to wait for its self-absorption; large blisters, you can be through the daily care, puncture drainage, and if necessary, topical medication and so on to deal with. 1. If the blisters are small, generally no special treatment is needed, waiting for its self-absorption. 2. Daily care: disinfect the blisters in time, avoid scratching and squeezing to avoid ulceration, pay attention to hand hygiene and cleanliness, and do a good job of protection to avoid continuous friction, which may aggravate the symptoms. 3. If the blister is large, you can use a syringe under the guidance of a doctor to draw out the pus in the blister, or puncture the blister to drain the fluid, if the blister itself has been ruptured, it is necessary to prevent infection, to make local wet compresses, such as isacridine or rehabilitation of new liquid to do wet compresses, if necessary, topical ointment, such as mupirocin ointment, compound polymyxin B, or fusidic acid topical use, the use of drugs, please follow the instructions of the doctor.