Prostate cancer is a malignant tumor that poses a serious threat to the health of older men, and its incidence has continued to rise in recent years. Depending on the grading and staging of prostate cancer, there are different treatment options such as radical prostatectomy, endocrine therapy, and radical radiation therapy. Of course, the most ideal treatment for prostate cancer patients is radical resection surgery, but the requirements are high. Many patients lose the chance of radical surgery because of the surrounding invasion of the tumor or lymph nodes or distant metastasis at the time of discovery, and endocrine therapy can be used at this time. Endocrine therapy includes depot treatment, anti-androgen drug therapy, and pharmacological treatment such as inhibition of androgen synthesis.
Destructive therapy includes two modalities: 1. Destructive surgery; and 2. Destructive drugs. The effect of androgen level reduction is definite, but because orchiectomy is irreversible and causes direct changes in the patient’s appearance, many reports have confirmed the adverse psychological effects of denervation surgery, and because denervation drugs, such as leuprolide, are also effective in blocking the gonadal axis, denervation drugs have largely replaced denervation surgery in clinical practice. It is important to note that the use of debulking drugs can cause a rise in androgens during the first week, so anti-androgen drugs need to be used at the same time to prevent the aggravation of prostate cancer.