Hand, foot and mouth disease is an acute febrile rash disease caused by enterovirus infection, which is relatively contagious. Its source of infection is mainly patients with HFMD as well as hidden infections, and there are usually the following ways of transmission: first, the most important way of transmission is close contact, if close contact with HFMD patients, living together, touching the toys the child has played with, used utensils, etc. may be infected. The second, through airborne transmission, because children with HFMD may have varying degrees of coughing, at this time will also discharge the virus of HFMD, close contact, spending a long time together can also lead to infection. Third, playing with children, contact with children’s excrement, such as feces, urine, etc. also have a certain degree of contagious.