Pregnancy increases the demand for insulin in pregnant women, the secretion of thyroxine, adrenocorticotropic hormone and growth hormone increases during pregnancy, especially the placental hormones such as placental lactogen, estrogen and progesterone increase significantly in the middle and late pregnancy, these hormones can reduce the sensitivity of surrounding tissues to insulin, on the other hand, the insulinase produced by the placenta has increased the degradation of insulin, increasing the burden of pregnant women, the insulin The demand for insulin is increased by a factor of 1 compared to non-pregnancy. Pregnancy can lead to the manifestation of latent diabetes, the development of GDM in pregnant women without diabetes, and the aggravation of pre-existing diabetes. As the pregnancy progresses, the amount of insulin needs to be increased, and the physical exertion during labor is high and the amount of food is low, if the amount of insulin is not reduced in time, hypoglycemia is likely to occur. As the placenta wanders out, the anti-insulin substance secreted by the placenta disappears rapidly, and the amount of insulin should be reduced immediately, otherwise hypoglycemic shock is likely to occur. Due to the complex changes of glucose metabolism during pregnancy, if the insulin dosage is not adjusted in time, some patients may develop hypoglycemia, and in serious cases, it may even lead to hypoglycemic coma and sexual ketoacidosis.
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