If there is itching and discomfort in the urethra with clear discharge from the external urethra, non-gonococcal urethritis due to mycoplasma or chlamydia infection may be considered. Non-gonococcal urethritis is a common clinical manifestation of UTI, but its clinical manifestations are less severe than those of gonorrhea. Non-gonococcal urethritis is often characterized by mucus or mucopurulent discharge from the external urethra in relatively small amounts, usually requiring hand pressure on the urethra before it may overflow, and its incubation period is usually 1-3 weeks. It often appears after gonorrhea has been cured and is also known as post-gonorrheal urethritis. Female patients may have urethritis, but the symptoms are not very pronounced and will instead present as cervicitis, with the causative organisms usually being chlamydia, mycoplasma, fungal trichomonas or acrodermatitis and herpes virus. If these manifestations occur, it is recommended to visit the urology department of a regular hospital. It is necessary to evaluate the condition by improving blood routine, blood inflammation index, urine routine, urethral swab examination, urine culture plus drug sensitivity test under the guidance of physician. If the relevant laboratory tests confirm the diagnosis of mycoplasma or chlamydia infection, it is recommended to apply drugs such as doxycycline, tetracycline, azithromycin or levofloxacin for anti-infection treatment under the guidance of a physician. During the treatment period, attention should be paid to drinking more water, urinating regularly, and avoiding spicy and other stimulating foods. It is recommended that sexual partners should also be actively treated.