High-grade intestinal intraepithelial neoplasia can be cured by resection. High-grade intestinal intraepithelial neoplasia is a precancerous lesion, which refers to cancerous changes in the intestinal epithelial cells that have not broken through the basement membrane to infiltrate. If high-grade intestinal intraepithelial neoplasia occurs, it is important to treat it as soon as possible to prevent it from progressing into invasive cancer. The disease is usually treated using surgery, which consists of two types: minimally invasive endoscopic resection and direct surgical resection. Minimally invasive endoscopic resection is less invasive, quicker to recover, and less expensive, making it the treatment of choice. Direct surgical resection is to remove the entire intestine where the lesion is located, which has the advantage of a wide range of resection, but is more damaging. If the diagnosis is high-grade intestinal intraepithelial neoplasia, the patient should consult the gastroenterology department or general surgery department in a timely manner, so as to improve the prognosis and reduce the complications through early and standardized treatment under the guidance of professional doctors.