Under normal circumstances, the body is negative for anti-histone antibodies. Therefore, if there is a positive change in the anti-histone antibody, it is usually a pathological lesion. The most common diseases are connective tissue diseases, such as rheumatoid arthritis, rheumatoid arthritis, systemic lupus erythematosus, and immune system diseases, such as dry syndrome, all of which are weakly positive for anti-histone antibodies. Some chronic infectious liver diseases, such as chronic infectious hepatitis or biliary cirrhosis, may also result in weak anti-histone antibody positivity.