No antiviral drugs have been developed that specifically target monkeypox virus, and treatment with anti-DNA virus drugs can be attempted in combination with supportive care and treatment of complications. For the time being, monkeypox is a self-limiting disease, and most patients have a favorable prognosis. For young children and immunocompromised people, serious complications may occur. 1. Drug therapy: Currently, no antiviral drugs have been developed to specifically target the monkeypox virus, but we can try to treat the disease with anti-DNA viruses, such as acyclovir and valacyclovir, but the medication should be used in accordance with the doctor’s instructions. 2. Symptomatic supportive treatment: if there is fever, physical cooling can be given, antipyretic drugs such as ibuprofen, etc.; patients should strengthen the rest, nutrition and hydration, maintain the balance of water and electrolytes; blister rupture, if secondary infection, can be given to anti-infective drugs, such as ceftriaxone, amoxicillin and so on. 3. Actively prevent and treat complications: such as encephalitis, bacterial infection, bronchopneumonia and other life-threatening symptoms. For example, sedation, dehydration to lower cranial pressure, and airway protection can be given when the patient develops encephalitis. Infection with monkeypox virus requires active cooperation with the doctor’s treatment and relevant isolation and protection without delay.