Microangiopathy generally refers to lesions of blood vessels other than large, medium and small vessels, mainly due to changes in the function of the microvasculature, causing endothelial damage, thickening of the basement membrane, increased blood viscosity and aggregation of red blood cells, platelet adhesion and aggregation, and finally microthrombosis and occlusion of microvasculature. This condition often causes extensive systemic lesions, including some retinal lesions and renal lesions, sometimes even leading to nephropathy, renal failure and uremia and death, as well as extensive sclerosis of blood vessels and microvascular lesions of the heart, which can lead to heart failure and even sudden death. This microcirculatory lesion can also involve all parts of the body where microvascular beds exist, including the extremities, skin, subcutaneous tissues and skeletal muscles, so it is important to pay full attention to this ischemic change that appears to have good blood flow, but in fact the microvasculature is already diseased.