Tacrolimus ointment and pimecrolimus ointment are both used in the treatment of atopic dermatitis, but the two drugs are slightly different in terms of the type of drug, contraindications for use by the population and so on. The clinical need for symptomatic treatment, there is no argument that one drug is more effective. 1. Tacrolimus ointment: it is a topical skin medication mainly used as a short-term or intermittent long-term treatment for patients with moderate to severe atopic dermatitis who are not suitable for traditional therapies due to the potential risk of non-immune impairment, or who have not responded adequately to, or are unable to tolerate, traditional therapies. Use in malignant skin diseases such as cutaneous T-cell lymphoma should be avoided. Adverse reactions such as burning sensation and itching of the skin may occur when tacrolimus ointment is applied topically. It is contraindicated in patients with hypersensitivity to macrolides, tacrolimus, children under 2 years of age, and women during pregnancy. Hepatic and renal insufficiency, diabetes mellitus, hyperkalemia, ventricular hypertrophy, lactating women should be cautious. 2. Pimecrolimus Ointment: is a cutaneous immunomodulatory drug used for the treatment of mild to moderate atopic dermatitis (eczema) in non-immunocompromised patients 2 years of age and older. Topical application of this product should be avoided when infection occurs at the site of the lesion to prevent aggravation of the associated disease. Adverse reactions such as burning sensation at the site of application, itching, and erythema may occur after administration, and prolonged use may lead to skin infections. It is contraindicated in patients who are allergic to pimecrolimus and other poly lactams. Use with caution in pregnant and lactating women. If you need to use tacrolimus ointment or pimecrolimus ointment, you should go to the hospital, according to their own specific conditions and actively cooperate with the doctor’s treatment plan, follow the doctor’s instructions, do not blindly use the drug.