Running lateral ankle pain may be caused by excessive friction, acute trauma, ankle sprain, degenerative arthritis of the ankle joint and other factors. 1. Excessive friction: wearing inappropriate shoes and running for too long may lead to excessive friction of the skin on the outer side of the ankle, which may cause localized skin damage, and then lead to pain on the outer side of the ankle, mainly on the outer side of the ankle. 2. Acute trauma: when running, the outside of the ankle touches some hard objects, resulting in acute injury to the outside of the ankle, which also easily causes pain on the outside of the ankle, and may be accompanied by subcutaneous bruising, swelling and other symptoms. 3. Ankle sprain: Incorrect running posture or uneven road may cause ankle sprain, which may easily cause lateral ankle pain, and may be accompanied by limited ankle movement, swelling and other symptoms. 4. Degenerative arthritis of the ankle joint: mainly in the elderly group, due to the presence of degenerative arthritis of the ankle joint, when running, it may aggravate the lesion, which will cause lateral ankle pain. If you have pain on the outside of the ankle, you should stop running immediately and take reasonable rest, and when the pain is more serious, it is recommended to consult a doctor for examination and treatment.