Among the human skeletal tissues, the skull is a very hard bone, and its role is pivotal, as it supports and protects the human head and face, and maintains the normal intracranial environment and intracranial pressure. However, there are too many risk factors in life that can lead to cranial defects, so that the brain lacks external protection, and the danger will be greater if not remedied in time. Craniosynostosis will affect the appearance, and patients will become very low self-esteem; craniosynostosis will change the intracranial pressure and intracranial environment, thus interfering with the normal operation of intracranial life activities; craniosynostosis will also lead to a series of neurological dysfunction, causing craniosynostosis syndrome, the specific performance can be headache and dizziness, loss of muscle strength of the limbs, inattention, irritability, irritability and so on. Therefore, for cranial defects, it is clinically recommended that patients with a defect diameter greater than 3cm and who are eligible for surgery should go to a professional hospital for cranial repair surgery in time, so as to better restore the integrity of the skull and reshape the closed and stable cranial cavity environment to avoid causing more damage to themselves. When it comes to surgery patients are more worried about the risk, but in fact skull repair surgery in neurosurgery is not too big surgery, safety is still quite high, patients do not have to worry too much, the focus is to choose good repair materials and experienced doctors to do the surgery, so as to greatly improve the success rate of surgery. At present, most hospitals are using titanium mesh material, although there are some advances in titanium mesh material, but there are also some unavoidable problems, so it is not yet a very ideal choice.