Argon-Helium Targeted Cryosurgery System (Ar-He knife for short) is a multi-probe, high precision, rapid freezing and rapid re-warming surgical system, which is a medical technology with dual functions of ultra-low temperature and thermal effect, successfully developed by adopting American space technology and several European and American patents. Argon Helium Knife for Liver Cancer At present, ultrasound-guided percutaneous cryoablation for liver cancer has achieved obvious efficacy. It is characterized by certain efficacy, low invasiveness, simple implementation, high reproducibility and high benefit-cost ratio. Especially for those patients with large tumors (>8cm) that could not be surgically resected by surgical standards in the past, this method has now been widely accepted, and more importantly, it has become the treatment of choice for those patients with multiple lesions in the liver or those with difficult to resect tumor sites and limited liver function. (1) Indications ① primary or metastatic hepatocellular carcinoma with mass diameter of 1~15cm; ② no more than 4 intrahepatic lesions and no extrahepatic metastatic lesions; ③ large hepatocellular carcinoma with more than one of the following conditions: a. Patients with good general condition, no obvious malignant mass, ultrasound, CT and other imaging examinations to exclude the existence of obvious cancer thrombus in large intrahepatic vessels and multiple metastatic carcinomas outside the liver. b. Combined with other non-surgical treatments for liver cancer such as hepatic artery cannula embolization, hepatic artery or portal vein chemotherapy, radiation therapy, etc. to further improve the efficacy. c. Those who are not suitable for other methods of treatment due to the limitation of tumor site or patient’s condition. ④Primary hepatocellular carcinoma with combined cirrhosis, without intractable ascites, with liver function of Child grade A or B. ⑤ Patients with liver metastases who must have the primary tumor lesions removed and have contraindications to chemotherapy, refuse chemotherapy or fail chemotherapy. (2) The advantages of this therapy are: ① Targeted inactivation of tumor cells and destruction of only intrahepatic tumor tissue with less damage to surrounding normal tissues, which is especially important for patients with liver cancer with cirrhosis and poor liver reserve capacity; ② Tumors adjacent to large blood vessels can be safely treated with cryotherapy due to the flow-through effect of blood, while surgical removal of these tumors is often difficult; ③ It can effectively treat huge or multiple liver tumors. It can be single or multiple treatments; ④ The dead tumor tissues left in the body can be secondary to the immune reaction against tumor cells; ⑤ Freezing can promote the chemotherapy drugs to enter into the tumor cells, so there are advocates to apply chemical drugs at the same time of cold ablation to destroy the residual living tumor cells, which is cold chemotherapy; ⑥ It can be combined with surgery, radiotherapy and arterial intervention to improve the therapeutic effect. Cryoablation is still effective for patients who have failed radiotherapy or chemotherapy. Cold ablation is a relatively safe treatment method with fewer complications and better efficacy, which is popular among patients. Ar-He knife treatment for lung cancer The features of percutaneous lung puncture Ar-He knife treatment for lung cancer are: (1) no incision, less trauma, no significant pain, and fast recovery after surgery; (2) death of tumor cells, reduction of compression, shrinkage of tumor body after 1 to 3 months, and improvement of clinical symptoms; (3) reactivation of body immune system, which is conducive to the improvement of survival quality; (4) efficacy is similar to surgical resection, and can be repeatedly frozen, and can be combined with radiotherapy and chemotherapy; (5) efficacy is similar to surgical resection. (5) It is suitable for patients with all stages of lung cancer: early stage lung cancer can achieve radical effect, while late stage lung cancer is a palliative surgery to reduce the tumor load, which is still suitable for patients with poor physical condition and failure of other treatments. Indications: (1) single or multiple, primary or secondary peripheral lung masses with a single tumor diameter >1.0 cm; (2) central lung cancer that cannot be resected by surgical exploration; (3) metastatic lung cancer whose primary cancer is well controlled or more limited; (4) huge cancer involving the mediastinum and pericardium, but without extensive metastasis, reduction of tumor load cryosurgery is still feasible; (5) patients with malignant pleural fluid, but the primary focus is (5) with malignant pleural fluid, but the primary focus is clear.