Most cases of premature ovarian failure are in women before the age of 40, when the ovaries are failing and reaching a state of menopause. This has a lot to do with early onset ovarian insufficiency, which is caused by the following aspects: 1. Genetic factors. The most common causes of ovarian insufficiency are autoimmune diseases and infectious diseases, which can damage the ovarian tissue and cause premature ovarian insufficiency. 3. Medical factors. In this case, the ovarian tissues are damaged by surgery, which affects the blood supply to the ovaries and leads to ovarian insufficiency. 4. Adverse environment. If a woman is in an environment of high radiation or toxic substances for a long time, she is likely to suffer from ovarian insufficiency, leading to premature ovarian failure. 5. Bad habits. If you have a long time to stay up late, a lot of smoking and alcohol abuse, it will also lead to ovarian insufficiency and premature failure of the ovaries.