Ophthalmoplegia is one of the clinical symptoms of pediatric oculo-ocular-spinal syndrome. What are some of the most confusing symptoms of oculoconjunctivitis? Small eye fissures: The eye fissure is the gap between the upper and lower eyelids, which is commonly referred to as the eye slit. The most important factor affecting the size of the eye fissure is the inner canthus, followed by the outer canthus. The inner canthus refers to an additional half-moon skin fold at the inner corner of the eye that connects the upper and lower eyelids, covering the intersection of the upper and lower lines of the inner canthus, the inner lake, and the meatus, making the inner corner of the eye an obtuse angle, giving the impression of a widened orbital distance and shortened eye fissure. Strabismus: There are many kinds of strabismus, the most common one is inward strabismus, which is medically known as internal strabismus, commonly known as crossed eyes and crossed eyes. The most common type of strabismus is the outward deviation of the eyeballs, which is called exotropia, commonly known as oblique white eyes. Of course, strabismus does not only refer to cases in which the relative position of the two eyes is obviously deformed, but also includes cases in which the obliquity is so small that it is not easily detectable on the surface, but the visual function of both eyes is not normal, and also includes those cases in which there is no oblique position at all but both eyes are not normal. Therefore, the concept of strabismus should be understood as an abnormality in both the relative position of the two eyes and the binocular visual function. Optic disc tilt: Degenerative myopia presents with an optic disc tilt with a myopic arc. As the posterior part of the wall of the highly myopic eye bulges backwards, the optic nerve enters the globe obliquely. One side of the optic disc (mostly the temporal side) is displaced backward, causing the disc to lose its normal slightly vertical oval shape under the examining eye and become a significant vertical (or lateral or oblique) oval shape, even like a skip. There is a crescent-shaped spot connected with the posteriorly shifted side, called myopic arc (conus, or extended myopic arc, extensive conus). The upward traction arc (supertractionconus) is a slightly brown, blurred, crest-like elevation of the contralateral optic disc margin. The medial side of the extended myopic arc is white, due to scleral exposure, and the lateral side is light brown, due to loss of the pigment epithelium and exposure of the choroid. The lateral border of the myopic arc is clear, but is often contiguous with the posterior pole atrophy area. In most cases, the myopic arc is located temporal to the optic disc, but also superior or inferior temporal. More rarely, it is located on the nasal or inferior side, and the former is called the inverse myopic arc (inversiveconus); the latter is called the Fuchs arc (Fuchsconus). When the temporal myopic arc extends outward, upward, and downward continuously, it can surround the entire optic disc, which is peripapillary chorioretinal atrophy (circumpapillarychorioretinalatrophy). This syndrome occurs in 60% to 70% of cases in boys, and its clinical manifestations are more complex. About 10% of cases are mentally retarded, while most cases show only partial signs. The main signs are as follows. 1. Eyes with corneal dermatomas, eyelid defects, ptosis, small corneas and small eyeballs, crooked eye fissures, cataracts, etc. 2.Ear with pars plana, preauricular fistula, deafness and external auditory canal defect. 3.Facial deformities such as small jaw deformity, hare lip, giant mouth (transverse cheek cleft), zygomatic bone hypoplasia, teeth misalignment, etc. 4.Spinal deformity is manifested as different forms of scoliosis and bone healing, but there may also be rib abnormalities, skull deformities, limb and foot deformities. 5.Other malformations may include cardiovascular malformations, lung, kidney, dental and intellectual abnormalities. In the five cases reported by Zhou Daohua et al, all of them were born with onset of disease. Three cases had upper eyelid defects, two cases had small eyeballs and small corneas, and one case had cryptophthalmos without normal intraocular structures. two cases had preauricular malformations and one case had a congenital fistula combined with deafness. one case had a longitudinal scar in the center of the nasal bridge with a scar length of about 18 mm, and the other case had a nasal malformation. X-rays showed scoliosis of the thoracic spine with wedge-shaped healing of the bone. In addition, there were abnormalities such as mental retardation, forehead protrusion, harelip, cleft palate, and misaligned teeth. Histopathological examination of the corneal surface superfluous organisms confirmed corneal dermatoma. Diagnosis was made based on the presence of coexisting abnormal signs such as ocular-ear-spinal. Chromosomal examination was normal.