Because of the limited efficacy of antiviral treatment for chronic hepatitis B, it cannot completely remove the virus, thus leading some patients to have better results during the use of antiviral treatment, but then relapse after stopping the drug. Some of these patients have the idea of backing off after spending a large amount of money, thinking that slow hepatitis B treatment is always incurable, so they should simply stop treating it. This kind of thinking is extremely wrong, if the condition requires, it is necessary to treat, otherwise the liver condition will aggravate, and eventually may develop to cirrhosis. Therefore, patients with chronic hepatitis B must establish the concept of long-term treatment, we call this antiviral treatment cyclic therapy, which means that no current drug can completely cure hepatitis B through a course of treatment, but through multiple courses of treatment, the application of multiple drugs to continuously control viral replication and stop the further development of the disease. In addition, regular checkups during treatment are also very important. We often encounter patients who are prescribed medication and do not ask for checkups, thinking that it is more important to take medication and it does not matter if they are checked or not. In fact, regular checkups are no less important than regular medication. Because regular checkups can monitor the effect of antiviral treatment, if antiviral drug treatment is ineffective, it should be replaced by other antiviral drug treatment; if the efficacy is achieved, continue treatment for a period of time and then stop the drug; if the rebound of HBVDNA and ALT occurs during the medication, it may be because the virus has mutated and become resistant to the drug. There are also some antiviral drugs that may cause some adverse reactions during treatment, such as interferon may cause a decrease in white blood cells and abnormal liver function, and individual patients may have abnormal thyroid function. These need to be checked regularly to be detected in time. Some patients are not monitored during medication, so that doctors are unable to judge the efficacy of the drugs, and some adverse reactions cannot be detected in time, and the patients themselves are the ones who are ultimately damaged.