Nifedipine is a dihydropyridine calcium antagonist, mainly used in the treatment of hypertension, coronary heart disease and chronic stable angina. Nifedipine dilates coronary arteries, especially large blood vessels, which can reduce the tension of coronary artery smooth muscle, prevent vasospasm, increase blood flow to narrowed vessels, and improve oxygen supply. At the same time, nifedipine reduces oxygen demand because it lowers peripheral resistance. Long-term use of nifedipine prevents the development of new coronary atherosclerotic disease. Adverse effects of nifedipine include headache, edema, vasodilation, and constipation. Great care should be taken in patients with heart failure and aortic stenosis, when the blood pressure is very low, taking this product. Caution should also be exercised when using this drug in patients with severe gastrointestinal stenosis. Contraindications are: known hypersensitivity to nifedipine or any of its components, cardiogenic shock and women within 20 weeks of pregnancy and lactation. It can not be used in combination with rifampicin. Nifedipine has many adverse effects, it is recommended to use the drug under the guidance of a doctor.