Ziprasidone and olanzapine can both treat schizophrenia, but there are differences in clinical application, and it is not possible to say that that one has fewer side effects, only that it is more suitable for which drug. Ziprasidone is an atypical antipsychotic medication that is primarily used in clinical practice to treat schizophrenia. Adverse effects such as abdominal pain, fever, facial edema, drowsiness, respiratory infections, loss of appetite, vomiting, anemia, inability to sit still with thirst, and dizziness may occur with the use of ziprasidone. Olanzapine also belongs to the antipsychotic drugs, which are mainly used in the clinic for the treatment of schizophrenia and moderate and severe manic episodes. Common adverse reactions to olanzapine include drowsiness and weight gain, but dizziness, increased appetite, inability to sit still, peripheral edema, upright hypotension, and dry mouth may also occur. Both ziprasidone and olanzapine are prescription medications, and you should consult with a medical professional about which medication you should choose and use and follow your doctor’s instructions to the letter in order to avoid adverse reactions.