Monkeypox virus can cause a zoonotic viral infectious disease called monkeypox, and its main clinical manifestations include rash, swollen lymph nodes, fever, and so on. 1. The incubation period of monkeypox is 6~13 days. Early onset of the disease usually appear moderate fever, body temperature more >38.5 ℃, can be accompanied by headache and other manifestations. A part of patients will appear inguinal, neck, armpit and other parts of the lymph nodes congestion and swelling. 2. Rash will appear about 2 days after the onset of the disease, which is a typical symptom of monkeypox. Rash first occurs in the face, and then will spread to the limbs, mostly centrifugal distribution, hands and feet can appear, and the number of general varies. It may also involve the mouth, genitals and cornea. The rash will go through several stages of changes from macules to papules to herpes to pustules, and can feel obvious itchiness and pain, about 2~4 weeks after the shedding. 3. Monkeypox is a self-limiting disease with a good prognosis for most patients. Severe cases are usually seen in young children, immunosuppressed, the prognosis is also related to the infected virus branch, the number of contacts with the virus, previous physical condition and other factors. If you have a history of traveling to a monkeypox infected area or suspect that you have monkeypox, please go to the hospital immediately to avoid delaying your condition and affecting your health.