Early stage pancreatic head cancer usually does not need chemotherapy before surgery, and most of them need to be resected by radical surgery after diagnosis, and chemotherapy can be adjuvant after surgery. The main purpose of pre-surgical chemotherapy is to reduce the tumor stage, mainly for the tumors that cannot be resected or inconvenient to be resected. Early pancreatic head cancer is confined to the inner part of pancreatic head, with no invasion to the surrounding tissues and no distant metastasis, so after the discovery of the lesion, it is enough to regulate the physical condition and undergo radical surgery to resect the lesion, and generally there is no need to treat with chemotherapy. Pancreatic cancer itself has a high degree of malignancy, and the prognosis is often poor, most of the patients need adjuvant chemotherapy after surgery, and standardized chemotherapy can maximally kill the tumor cells, and try to avoid the recurrence and metastasis of the tumor. Early pancreatic head cancer patients are recommended to consult doctor in time and choose appropriate treatment plan under doctor’s guidance to avoid delaying their condition.