Hepatitis B fibrosis, may appear weakness, loss of appetite, bleeding, pain in the liver area and other symptoms. 1. Fatigue: chronic inflammation and necrosis of liver cells caused by infection with hepatitis B virus leads to fibrosis of the liver. With the gradual decrease in the number of effective liver cells, the synthetic function of the liver will be affected, so that the synthesized energy and protein will be reduced, which may cause fatigue of the organism. 2. Loss of appetite: Hepatitis B fibrosis will affect the digestive function of the liver, resulting in gastrointestinal secretion and absorption function disorders, thus causing digestive symptoms such as nausea, bloating and loss of appetite. 3. Bleeding: Hepatitis B fibrosis leads to decrease in liver function, which affects the synthesis of prothrombin and other coagulation factors, and with decreased synthesis function, patients may have bleeding tendency, such as epistaxis and bleeding gums, bleeding spots on skin and mucous membranes and so on. 4. Pain in liver area: Due to liver fibrosis, the tension of liver periosteum is changed, which causes local pain and discomfort and the symptom of pain in liver area. If symptoms related to hepatitis B fibrosis appear, it is recommended to go to the hospital as soon as possible and follow the doctor’s advice to actively cooperate with the treatment according to the specific situation.