Three highs and one low is usually just a generalization, which may refer to a series of internal diseases, nephrotic syndrome, characteristics after the use of diuretics, or clinical symptoms of diabetic patients characteristics. We usually say three highs and one low, mainly refers to high blood pressure, high blood sugar, high blood fat, the age of onset is decreasing, showing a trend of rejuvenation. The three highs and one low in patients with nephrotic syndrome usually refer to high proteinuria, high degree of edema, hyperlipidemia and hypoproteinemia, and large amount of proteinuria is the most important manifestation of nephrotic syndrome. Generally after the use of diuretics, hyperglycemia, hyperuricemia, hyperlipidemia, and hyponatremia usually occur, presenting the characteristics of three highs and one low. Diabetes mellitus is characterized by three more and one less, which can also be interpreted as three highs and one low. The so-called three more and one less refers to excessive drinking, excessive urination, excessive eating and weight loss, which are the typical symptoms of diabetes mellitus. If the patient has the above symptoms of three highs and one low, he should consult a doctor in time to avoid delaying the treatment.