The name of dry syndrome is very unfamiliar to many people, and when we explain the disease to patients in the clinic, they often hear it as “liver syndrome”. Not to mention the people who have no medical knowledge, even many doctors have never heard of this disease. In the past, it was thought that dry syndrome was a rare disease, and people did not pay attention to it. In these years, with the development of medicine, our understanding of this disease has become more and more in-depth. Not only is dry syndrome not a rare disease, it is basically a common disease among elderly women, with an incidence rate as high as 3-5%. Dry syndrome is common in elderly women, but it can also be seen in men and young people, but in young people, the clinical manifestations of dry syndrome are not quite the same as those of the elderly. Older people usually present with dry mouth and eyes, a large number of dental caries, and teeth falling out in flakes, leaving tooth roots behind. Some patients with dry mouth and eyes need to keep drinking water, have difficulty swallowing dry food, and have blurred vision. In addition to these common symptoms, some patients with more severe types can also have reduced platelet leukocytes, interstitial pneumonia, renal lesions, cerebrovascular lesions, primary biliary cirrhosis, vascular embolism, and other visceral involvement. In young patients, dry mouth and eyes are generally uncommon, while involvement of the above-mentioned organs is more common. The diagnosis of dry syndrome is not difficult, as long as it is based on the typical symptoms of dry mouth and eyes, dental caries, dry red tongue, corneal damage, and check the blood autoantibodies, if anti-nuclear antibodies and SSA/SSB antibodies are found to be positive, the diagnosis is basically established. For individual difficult patients, lip gland biopsy or parotid gland imaging can be taken to further clarify the diagnosis. General rheumatologists are able to diagnose desiccation syndrome timely and accurately. In terms of treatment, because the difference between the severity and severity of patients with dry syndrome is very big, it will be different from person to person. Mild patients only need symptomatic treatment, more mouth rinsing, more teeth brushing and eye drops; severe ones need to be treated with hormones, immunosuppressants and so on. Therefore, if elderly women have dry mouth and eyes, many cavities, flaky teeth, dry eyes and old feeling of something in the eyes, they should be alert to dry syndrome and need to go to rheumatology and immunology department to investigate dry syndrome in time. As long as timely diagnosis and timely treatment, dry syndrome can generally be well controlled and there is no need to worry.