Modern medicine has researched the etiology and pathogenesis of psoriasis in many aspects, but there is no satisfactory treatment for the etiology and pathogenesis, which can only control the symptoms and cannot solve the problem of recurrence. The treatment of psoriasis is still at the stage of how to improve the efficacy, reduce the adverse effects, shorten the course of the disease and prolong the remission period. In front of hundreds of drugs and methods for treating psoriasis, how to choose and what to use correctly is the key to the success or failure of treatment, and is also the main concern of every patient. In order to standardize treatment and protect the interests of patients, we propose the following principles for choosing treatment methods to patients. 1, general considerations: (1) patients should understand matters: ① the disease generally does not damage the overall health, nor other organs, but sometimes mild inflammation of the joints; ② any treatment can not eradicate the disease, but there will indeed be less than a few months and more than a few years of remission; ③ through the treatment of lesions can be expected to disappear completely, some leave a very small number of lesions, as long as it does not affect the beauty, can not mind; ④ sometimes ⑤ It is not wise to blindly pursue “cure”. (2) Pay attention to any mental tension or mood swings during the acute onset or development of the disease, and it will be beneficial to give appropriate treatment when the condition is detected. (3) Check whether there are acute or chronic infection foci before the occurrence or aggravation of the disease, treatment or elimination of infection foci is sometimes effective, streptococcal pharyngitis induced dripping psoriasis is a prominent example. (4) Patients with psoriasis should avoid any external damage to the skin in order to reduce the resulting new skin lesions. Excessive scratching, sunburn and other trauma are harmful. 2, specific treatment principles (1) the use of principles of topical drugs: according to different periods in the course of the disease to give different treatment: ① in the progressive stage should be used mild and less stimulating drugs, so as to avoid aggravation of the lesions due to stimulation; ② in the stationary phase and the degenerative phase, can be used topically with higher concentrations of effective agents, but should also be used from a low concentration, so as to achieve both curative effect and less irritation, the increase in concentration should also be gradual, and The increase in concentration should be gradual, and attention should be paid to the occurrence of irritation at all times; (3) when using the drug, try it in a small area first, and increase the concentration only when the skin can tolerate it; (4) in the treatment, prefer to use less or no drugs with toxicity and easy sensitization. (2) Corticosteroids: internal or injectable corticosteroids should be prohibited in common psoriasis, and should be used only when other drugs are ineffective in erythrodermic, generalized pustular and arthritic psoriasis. A large number of corticosteroid preparations for external use may also produce systemic adverse reactions, which should be noted. (3) Immunosuppressants or anti-tumor drugs: such as leukemia, ethinylimine, etc. should not be used as much as possible, and should be prohibited for pregnant women. When no contraceptive measures, men should not be applied. Cyclosporine A has obvious adverse reactions and should only be used cautiously for pustular and arthritic psoriasis, and should also be prohibited for pregnant women. (4) Radix Rehmanniae: There are Radix Rehmanniae multi-tablets, Kunming Shanhaibang tablets and purified Radix Rehmanniae polyglucoside and other varieties. It has strong anti-inflammatory and immunosuppressive effects, and is effective for psoriasis with obvious inflammation, especially for erythrodermic psoriasis caused by drug stimulation. However, its adverse reactions are large, and the purified tretinoin is less toxic, which can cause nausea, vomiting, diarrhea, blood in stool, men’s sperm reduction and women’s menstrual disorders or amenorrhea or even sterility, and individual patients can also cause leukopenia, heart conduction block and liver and kidney dysfunction, so caution is needed when using it. (5) Retinoic acid and its derivatives: Various retinoic acid drugs are effective for psoriasis, among which aromatic retinoic acid and etretinate are one of the best drugs for psoriasis, especially for pustular and erythrodermic psoriasis, but retinoic acid has certain toxicity, so the following patients should not be used: women of childbearing age who are not subject to contraceptive measures, pregnant and lactating patients, patients with limited lesions of psoriasis vulgaris, and patients with psoriasis vulgaris. (6) Compound glycyrrhizic acid is not suitable for use in patients with severe liver function impairment. (6) Compound glycyrrhizin tablets: with strong anti-inflammatory and immunomodulatory effects, it can be used for the treatment of psoriasis with relatively small side effects. (7) Physical therapy: Chinese medicine bath, bran bath, tar bath and seawater bath all help to eliminate skin lesions. Sunlight irradiation and ultraviolet therapy or topical application of tar-like drugs plus ultraviolet irradiation, plus starch bath (triple therapy) are also effective and safe. The use of photochemotherapy is also effective, but attention should be paid to the secondary skin cancer when applied for a long time. (8) Proprietary Chinese medicines: Although the efficacy of some proprietary Chinese medicines cannot fully satisfy the patients, they can be used for psoriasis treatment because they are convenient to take and have few side effects. However, the use of the so-called “ancestral secret recipes”, “special effect pure Chinese medicine preparations” and some highly toxic single prescriptions and test prescriptions should be cautious and not to be fooled. In addition, there are also intravenous closed treatment, biofeedback therapy, etc. In general, there are many drugs and methods available for doctors and patients to choose for the treatment of psoriasis. As for how to choose the best treatment plan, it is very delicate for doctors, as individual patients differ greatly, and doctors need to treat patients according to their conditions. It is necessary to have efficacy, safety and reliability, and to save medical expenses. For drugs with serious adverse reactions, the indications and the course of treatment should be strictly controlled, and the treatment should not be excessive. Finally, the success of treatment depends not only on effective drugs, but also on the patient’s attitude toward the disease and confidence in treatment. Treating patients not only relies on anti-psoriasis therapies, but it is also very important to care and look after them, pay attention to avoiding risk factors that trigger and aggravate the disease, and change poor lifestyles.