The bacteria infecting appendicitis are mainly E. coli, enterococci, streptococci, faecal bacteria and anaerobic bacteria of the intestinal tract, which are medically classified as gram-negative bacteria. The commonly used effective antibiotics for Gram-negative bacteria are penicillin and cephalosporin antibiotics, but with the widespread use of antibiotics in daily life, the phenomenon of penicillin resistance is increasing, so the clinically recommended antibiotic of choice for appendicitis treatment is cephalosporin antibiotics. Whether after appendectomy or during conservative treatment of appendicitis drugs are preferred cephalosporin antibiotics, commonly used are second and third generation class cephalosporin antibiotics, such as cefamandole, cefmetazole, cefuroxime, ceftazidime, cefoperazone, etc.