Bone calcification refers to local bone calcium salt deposition, that is, a local increase in bone density, including non-pathological pathology. Non-pathological bone calcification is what is commonly referred to as osteophytes, which are degenerative changes in bone mass that occur with age, that is, the local blood supply is relatively poorer, producing pathophysiological changes. Because the local blood supply around the area is normal or more abundant, the surrounding cartilage appears to proliferate or harden, and osteophytes are formed. Pathologic osteophytes, such as metastatic calcification, occur in hyperparathyroidism or renal osteodystrophy and manifest as bone deposits outside of normal bone tissue. Pathological osteophytes can also be seen in osteodystrophy, where calcium is deposited into necrotic tissue, creating localized hyperplasia and calcification. Bone calcification can be non-pathologic or pathologic and should be identified and treated clinically for pathologic bone calcification, while non-pathologic bone calcification should be treated symptomatically or with other treatments depending on the patient’s symptoms.