Swelling and pain of ankle sprain may be caused by soft tissue injury, inflammatory exudation, venous and lymphatic reflux obstruction and other factors, which can be treated by cold compresses, drugs and other ways. 1. Soft tissue injury: sprained ankle if caused by soft tissue injury, can lead to local blood vessel rupture, causing local edema, swelling and pain. Local cold compresses can be applied to make the capillaries contract, play the role of hemostasis, swelling and pain. Under the guidance of the doctor can be used chlorzoxazone tablets, ibuprofen and other drugs, to promote soft tissue recovery, pain and other effects. 2. Inflammatory exudation: severe sprains of the ankle can lead to rupture of blood vessels on the surface of the joint capsule or tendon, causing tissue exudation, some of which may release significant inflammatory factors. Due to the action of inflammatory factors, the local inflammatory reaction is obvious, causing localized swelling and pain. The doctor may prescribe ibuprofen and other drugs to reduce swelling and pain. 3. Venous and lymphatic reflux obstruction: after ankle sprain, some patients’ braking or resting process may lead to poor venous and lymphatic reflux in the lower limb, causing local thrombosis, which may lead to localized swelling and pain. Microcirculation can be improved by elevating the affected limb and avoiding prolonged standing. Use drugs such as Diosmin tablets and Warfarin sodium tablets under doctor’s guidance. If the sprained ankle can not be relieved after proper rest, it is recommended to go to the hospital in time to clarify the cause of the disease and follow the doctor’s instructions to standardize the treatment, do not unauthorized use of drugs.