Coughing up sputum at night and dryness need to use penicillin, acetylcysteine effervescent tablets, compound boric acid solution and so on according to pneumonia, chronic lung disease, pharyngitis and so on respectively. 1. Pneumonia: it is a common disease that can cause coughing and sputum at night. According to the results of blood test and sputum culture, use penicillin and other antibiotics to control the infection, and then these symptoms can be relieved. 2. Chronic lung disease: mainly refers to chronic obstructive pulmonary disease (COPD), which is a typical disease that can cause sputum to be difficult to cough up, and acetylcysteine effervescent tablets can be used to dissolve mucous phlegm and assist in coughing up phlegm. 3. Pharyngitis: foreign body sensation in the throat area, difficult to cough up sputum is its typical symptom, you can use compound boric acid solution gargle for local treatment. The specific cause of the disease needs to be clarified after medical examination, and at the same time in accordance with the doctor’s instructions for treatment.