What are the triggers of epilepsy?

  Epilepsy, commonly known as “crohns” or “sheep epilepsy”, is a chronic disease in which sudden abnormal discharges of neurons in the brain cause transient brain dysfunction. The clinical manifestations of epileptic seizures are complex and varied due to the different starting sites and modes of transmission of abnormal discharges. The causes of epilepsy are diverse. After regular antiepileptic drug treatment, about 70% of patients with epilepsy can have their seizures controlled, and 50% to 60% of them can be cured after 2-5 years of treatment, and patients can work and live like normal people. According to the latest epidemiological data in China, the overall prevalence of epilepsy in China is 7.0‰, the annual incidence rate is 28.8/100,000, and the prevalence of active epilepsy with seizures within 1 year is 4.6‰. It is estimated that there are about 9 million epilepsy patients in China, of which 5-6 million are active epilepsy patients, while about 400,000 new epilepsy patients are added every year. Epilepsy has become the second most common disease after headache in neurology in China.  There are various triggers and factors for the onset of epilepsy, but also half of the patients have a difficult to find cause for primary epilepsy of unknown origin.  The common triggers and factors are as follows: 1. Traumatic epilepsy: Traumatic epilepsy refers to epilepsy caused by trauma. And it is often a local pathological change after trauma.  2. Brain diseases and systemic or systemic diseases: these are secondary epilepsies, such as cerebrovascular diseases, sequelae of encephalitis, brain occupying lesions, cysticercosis, etc. Except for vascular malformations that produce seizures at a younger age, cerebrovascular disease epilepsy is mostly seen in middle-aged and elderly people.  3, congenital encephalopathy: all congenital encephalopathies of the nervous system are accompanied by seizures as one of their symptoms.  4, congenital metabolic abnormalities and drug causes: abnormalities of cerebral lipid metabolism, glycogen deposition disorder, hemochromatosis. Phenylketonuria, etc. All have seizures as well as drug-related epilepsy.  5, age: age can be a factor for infantile convulsions, primary epilepsy occurs mostly before the age of 20.  6, genetic factors: genetic investigation studies have confirmed that genetic factors account for a certain percentage of primary and symptomatic epilepsy.  7, pathophysiology: in terms of neuronal electrical activity, interictal periods have both paroxysmal depolarizing activity, fulminant discharge, and hyperpolarizing waves; seizure neuronal electrical activity, synchronized discharge, paroxysmal stimulation; termination mechanism, still to be clear, but found that the appearance of intensity of hyperpolarization, can last for a period of time.  8, increased acetylcholine: studies have confirmed that the increase in acetylcholine and cholinesterase activity in the brain of epileptic patients is 25% and 35%, respectively. As a condition that promotes epileptic discharges.