The high incidence of cardiovascular and cerebrovascular events is between 6am and 12pm, while enteric aspirin takes 3-4 hours to reach its peak blood level after consumption. In addition, at night the human body is less active, the blood is sticky and platelets are easy to gather, therefore, enteric aspirin is more effective when taken at night. Aspirin should be taken at night before going to bed for the best reason: the role of aspirin is to inhibit the function of platelets in the blood. With more than 80% of platelet function inhibited in the body, cardiovascular disease can be prevented. About 1/10 of the body’s platelets are re-generated every day, so taking the drug once a day only requires the newly generated, functional platelets to be inhibited to maintain more than 90% of the platelets from functioning. Moreover, platelet newborn time is from 18:00 to 24:00 in the evening, and oral aspirin at night has the effect of lowering blood pressure, and no relevant effect during the daytime oral, so aspirin should be taken before bedtime. If the gastrointestinal symptoms are obvious after oral intake, you can take it orally after dinner.