The treatment plan for H. pylori treatment failure needs to be differentiated, if it is the first treatment that fails the treatment should be re-treated, if it is a refractory H. pylori infection can be treated by empirical eradication therapy or according to the results of drug sensitivity test.
If the first treatment failure of H. pylori, you can be re-treated after an interval of several months, so that the bacteria to restore the sensitivity to antibacterial drugs, at this time, you can take the four combination therapy with other remedial treatment. At the same time, it is important to implement scientific and standardized treatment methods.
For patients with refractory H. pylori infection, i.e., those who have not been successfully eradicated by standardized continuous eradication therapy with different drug combinations for ≥2 times and whose conditions permit, it is recommended that they undergo antibiotic susceptibility testing and bacterial culture for individualized diagnosis and treatment. High resistance rates should be excluded and antibiotics with high sensitivity should be selected.
Not only do we need antibiotics with high sensitivity, but we also need to have certain requirements for the PH environment in the stomach, and sufficient amount of questionable pump inhibitors or excellent quality acid inhibitors are also important factors affecting the success or failure of H. pylori eradication.
When H. pylori treatment failure occurs, it is recommended to visit a hospital and be treated under the guidance of a doctor.