Urinary creatinine 40,000 μmol/24h is not normal, has seriously exceeded the normal value range. Urinary creatinine increased pathologic factors can be seen in acromegaly, diabetes, hypothyroidism, etc.; physiological factors can be seen in a large amount of meat, strenuous exercise, etc.. Urine creatinine general normal range standard for adult men 7000 ~ 18000 μmol / 24h, adult women 5300 ~ 16000 μmol / 24h. 40,000 μmol / 24h belongs to the urinary creatinine is elevated. Creatinine is a product of muscle metabolism, which is mainly cleared by the kidneys, and every 20g of muscle metabolism can produce 1mg of creatinine. Increased urinary creatinine can be seen in pathological conditions such as acromegaly, diabetes mellitus, hypothyroidism, etc.; physiological conditions such as eating a lot of meat, strenuous exercise, etc.. If the urine creatinine reaches 40,000μmol/L, it is recommended to go to a regular hospital as soon as possible, follow the doctor’s instructions to complete the relevant examinations, and carry out standardized treatment.