Patients with high-risk stage II colon cancer need to follow doctor’s instruction for surgical treatment and chemotherapy. 1. Surgery: Usually, patients need to undergo conventional open surgery or laparoscopic surgery under the guidance of doctors according to their own conditions, and according to different parts of the body, the operation methods are also different, which mainly include transverse colon resection, right hemicolectomy, left hemicolectomy, sigmoidectomy and so on. 2. Chemotherapy: patients with high risk of stage II colon cancer need to use chemotherapeutic drugs such as oxaliplatin, capecitabine and other chemotherapeutic drugs according to doctor’s prescription, but some patients may have gastrointestinal reactions, hand-foot syndrome, bone marrow suppression, liver function impairment and other adverse reactions after treatment. It is recommended that patients with high-risk stage II colon cancer should choose reasonable treatment measures under the guidance of doctors and take good care of themselves.