Numbness of hands and feet needs to be identified and treated first. Physiologic numbness of hands and feet may be related to poor posture. Pathological numbness may be related to cervical spondylosis, cerebral infarction, diabetic peripheral neuropathy and so on. It is recommended that patients go to the hospital in time to improve the relevant examination. 1. Physiological: numbness of hands and feet is commonly associated with prolonged standing, sedentary, stilted legs, etc. When the nerves are compressed for a long time, it will lead to numbness of hands and feet. It is usually transient and can be relieved by itself. 2. Pathological (1) Cervical spondylosis: cervical spondylosis can lead to numbness of hands and feet. The main treatment is surgery, which can remove the tissues that constitute pressure on the nerves. Medications can also be used to relieve the discomfort. (2) Cerebral infarction: When patients experience numbness in the hands and feet on the same side of the body, it is likely to be caused by cerebral infarction. Thrombolysis can be performed with drugs such as recombinant tissue-type fibrinogen activator. (3) Diabetic peripheral neuropathy: It can lead to numbness in the distal limbs, hands and feet. It can be treated with drugs such as Epalrestat and Mecobalamin. It is recommended that patients with symptoms of numbness in hands and feet go to the hospital in time to improve the relevant examination and standardize the treatment.