Syphilis titer, i.e. non-specific syphilis spirochete antibody titer, usually 1:1 negative is the normal value, generally the closer the value is to 1:1, the easier it is to turn negative. When a patient is infected with syphilis, non-specific anti-lipid-like antibodies (reactive elements) will be produced in the serum, and the level of its titer is directly proportional to the disease activity and infectiousness, i.e., the higher the titer, the higher the activity of the disease and the more infectious it is. Usually, this indicator is also used to observe the effect of syphilis treatment and to determine relapse and re-infection. A non-specific syphilis antibody titer is usually defined as a 1:1 negative, i.e. the higher the titer, the more likely it is to be negative. However, it should be noted that whether the syphilis patient is cured or infectious, not only depends on whether the syphilis titer is negative, but also combined with the patient’s clinical symptoms and other aspects of comprehensive judgment. Clinically, there are still a few patients by the regular anti-syphilis treatment, its non-specific syphilis spirochete antibody titer may be in a long time (or even lifelong) to maintain in a low level, that is, serofixed patients, this part of the patient in the comprehensive checkups, to exclude the re-infection and neurosyphilis and other conditions, no longer infectious, but need regular physical examination and re-check titer and so on. Syphilis is very damaging to the human body, if the result of non-specific syphilis spirochete serology is positive, it is recommended to go to a regular hospital in a timely manner, a comprehensive physical examination and other related tests to clarify the diagnosis and standardize the treatment under the guidance of the doctor.