Thyroid nodule grade 3 is usually allowed to get the new crown booster shot. However, if abnormal thyroid function occurs, or if the patient’s physical condition is poor, the new crown vaccination is usually postponed, so as not to affect the effectiveness of the vaccine. Thyroid nodule grade 3, if the patient has no uncomfortable symptoms, is generally not a contraindication to the new crown vaccination, can be vaccinated with the new crown vaccine booster shot. It will not affect the patient’s condition and has little effect on the effectiveness of the vaccine. If the patient has abnormal thyroid function, such as symptoms of hyperthyroidism, such as insomnia, agitation, increased heart rate, etc., it is generally recommended to postpone the New Crown vaccination. If symptoms of hypothyroidism are present, such as weight gain, facial swelling, memory loss, etc., or if the patient’s resistance is poor, New Crown vaccination is also withheld. Wait until the condition is stabilized before considering the New Crown Vaccine. Generally speaking, patients with grade 3 thyroid disease can be vaccinated if their condition is stabilized; if their condition is in the acute stage, it is recommended to postpone the vaccination and consult with the doctor before vaccination so as not to affect the effect of the vaccine or the recovery of their condition.