When acne appears on the face with obvious pain to touch, consider the possibility that acne has formed after a bacterial infection. Acne is one of the types of folliculitis. Because of long-term staying up late, eating chili peppers, anxiety, fire or high secretion of androgens in the body, causing the sebaceous glands to secrete a large amount of sebum to block the pores, it will put the inside of the hair follicles in an anaerobic state, prompting the growth of a large number of anaerobic bacteria, which will lead to severe pain. This situation can choose to use oral medication with topical medication, oral doxycycline or minocycline, in the local use of fusidic acid cream or mupirocin cream, continuous treatment for a period of time, the pain symptoms will gradually subside. Usually reduce staying up late, eat less chili peppers, reduce the degree of sebaceous gland secretion, to achieve the role of auxiliary treatment.