Generally speaking, if there is an underlying gastric disease, doctors will not fail to recommend checking H. pylori. Screening for H. pylori has significance for clinical treatment, but there are some groups of people who are not suitable for H. pylori checking. There are four main screening methods for H. pylori: blood test, C13 and C14 urea breath test, saliva test, gastroscopy and gastric mucosal biopsy. The first three of them can be used as preliminary screening, and the last one can confirm the diagnosis, but it is not recommended to do this test if you have poor coagulation function or gastric hemangioma. Helicobacter pylori is the most common chronic bacterial infection in human beings. According to statistics, the rate of Helicobacter pylori infection in China ranges from 40% to 90%, with an average of 59%. In recent years, a series of studies have shown that H. pylori significantly increases the risk of gastric cancer, and at the same time, people have found multiple mechanisms by which H. pylori causes cancer. Therefore, screening for H. pylori is essential for people with underlying gastric disease. Excluding contraindications, screening for H. pylori is more significant for screening for early cancer and people with underlying gastric disease. If there is any discomfort, one should consult a doctor and follow the doctor’s instructions for examination and treatment.