Urinary light chain kap value of 43mg/dl means that urinary light chain kap is significantly elevated, clinically, urinary light chain is mostly common in multiple myeloma, plasma cell leukemia and other diseases, but also chronic renal failure, infections and other factors can also lead to its elevation.
Immunoglobulin consists of two light chains and two heavy chains, the light chains include kap and lam, the normal value of light chain protein kap in urine should be less than 5.1mg/dl, and the ratio of lam is about two.
The molecular weight of urinary light chain kap is relatively small, and more than 90% of urinary light chain kap is reabsorbed in the proximal tubule after filtration from the glomerulus. If the urinary light chain kap value is significantly elevated, first consider the possibility that it is caused by monoclonal increase.
In multiple myeloma and plasma cell leukemia, the body will secrete a large number of monoclonal immunoglobulin kap, glomerular filtration capacity of urinary kap light chain, more than the proximal tubular reabsorption capacity, at this time there will be urinary light chain kap elevation.
In addition, elevated urinary light chain kap may also be seen in acute and chronic hepatitis, severe infections and malignant tumors, autoimmune diseases, chronic renal failure, nephrotic syndrome and other patients, the magnitude of the increase will not be very large.
Urine light chain kap elevation is recommended to further regular hospitals, improve the examination to clarify the cause of the disease, under the guidance of physicians standardized treatment.