Small blisters on the hand surface is very itchy, should first clarify the cause of the disease, and then for the cause of the targeted treatment and conditioning. Common causes are hand eczema, ringworm, sweating herpes, etc., in the treatment is mainly for the original cause of the application of drug therapy. 1. Hand eczema: If it is due to hand eczema, resulting in small blisters on the hands, very itchy. Can be directed by the doctor external rub halometasone cream, hydrocortisone cream and other glucocorticoid cream. Application of levocetirizine, loratadine and other antihistamines is conducive to the relief of clinical symptoms. 2. Ringworm: If ringworm causes small blisters and itching on the hands, anti-fungal creams such as terbinafine cream and miconazole nitrate cream can be applied. If the symptoms are serious, you need to take oral terbinafine tablets, itraconazole capsules and other antifungal drugs. 3. Sweat blisters: If the sweat blisters cause small blisters on the hands, very itchy, you can use topical glucocorticoid ointment such as mometasone furoate, hydrocortisone butyrate cream, or urea ointment, vitamin E ointment and so on. Itchy blisters on the hands, you should go to the regular hospital in a timely manner, after the cause of the disease is clear, by the doctor’s guidance to rationalize the application of drugs, to prevent their own blind abuse of drugs.