Overdose of antipyretic drugs can cause sweating, fatigue, etc.; there may be damage to the digestive tract; in severe cases, there may be liver and kidney damage, etc., which needs to be analyzed by specific symptoms. Overdose of antipyretic drugs can regulate the central temperature receptors in the brain, lowering the body’s temperature through increased sweating, excessive sweating can cause dehydration in the body, the patient’s body fatigue, weakness, thirst and so on. Most of the antipyretics are non-steroidal anti-inflammatory drugs (NSAIDs), overdose can cause digestive symptoms such as nausea, vomiting, etc.; for patients with ulcers, the use of large quantities can aggravate the symptoms of ulcers. Antipyretics are generally excreted by the liver and kidneys, and overdose can aggravate the metabolism of drugs in the liver and kidneys, which may result in impaired liver function, acute kidney injury and other diseases. Patients who have overdosed on antipyretic drugs should be hydrated in time, and if symptoms of discomfort or aggravation of existing illnesses occur, they should consult a doctor in time to avoid delaying their condition.