People spend about one-third of their lives in sleep, so the quality of sleep not only affects the quality of life, but also has a greater impact on the health of the human body, especially for those who suffer from chronic diseases. For chronic kidney disease, the quality of sleep is the key to ensure the stability of the internal environment of the human body, the internal environment is stable before the normal work of the organs of the human body in the normal state. We recommend an article that tells you how sleep deprivation is related to kidney? What should you do if you have to stay up late or work at night? How to manage kidney disease patients after insomnia? In short, paying attention to good sleep quality is a prerequisite for controlling kidney disease and preventing deterioration of kidney function! The theme of World Sleep Day 2018 is “regular rest, healthy sleep”. In recent years, with the development of sleep medicine, the impact of sleep on human health has gradually received the attention and attention of the public health community. A growing number of studies have shown that sleep deprivation is associated with decreased kidney function and risk factors for chronic kidney disease (CKD) – such as hypertension, diabetes and cardiovascular disease. What is the relationship between sleep deprivation and kidney? In 2012, scholars from Japan found that people who slept ≤6 hours per night had a 70% increased risk of proteinuria compared to those who slept 7 hours per night, and a 2016 study published by Kidney International again showed that proteinuria was twice as common in people who slept ≤5 h per night compared to those who slept 7-8 h, and that sleep deprivation was significantly associated with a rapid decline in kidney function. There was a significant association between sleep deprivation and rapid decline in kidney function. In 2017, a study published by the American Society of Nephrology Kidney Week also showed that chronic insomnia was associated with decreased kidney function, kidney failure and increased mortality. On the one hand, sleep deprivation can increase the risk of kidney injury; on the other hand, the microinflammatory state and uremic toxin accumulation in patients with chronic kidney disease can lead to sleep disturbances. The prevalence of insomnia in patients not on early hemodialysis has been reported to be 50%, while the prevalence of insomnia in maintenance hemodialysis patients can be as high as 80%. The two interact with each other to form a vicious cycle. Active management of insomnia can help prevent the onset and progression of chronic diseases such as CKD. What should you do if you have to stay up late and work night shifts? Health care workers are often required to work night shifts because of the nature of their jobs, and it is not easy to maintain healthy sleep habits. A recent article in the BMJ gives some advice on sleep for those who work night shifts. How to manage insomnia after kidney disease? Although there is no consensus on the specific treatment of insomnia in patients with kidney disease, the preferred non-pharmacological treatment for insomnia in patients with kidney disease is recommended. For example, adjust the patient’s sleep habits and sleep environment; do not use caffeine or stimulants before going to bed. If symptoms do not improve, cognitive behavioral therapy for insomnia (CBT-I) can be added, including 4 major parts of sleep hygiene, sleep restriction, stimulus control, and cognitive therapy. Medication may be given if non-pharmacological treatment is ineffective. Commonly used medications are non-benzodiazepine agonists (zolpidem, dexrazopiclone, zaleplon, and zopiclone), and no medication dose adjustment is required for patients with renal failure. Precautions for the use of drugs: use for short periods of time, start with low doses, titrate strictly, and monitor closely for adverse events.