Cardiovascular syphilis can be diagnosed by performing a serologic test for syphilis spirochetes as well as a serologic test for non-syphilis spirochetes, and the diagnosis is confirmed if both are positive. Cardiovascular syphilis is an advanced form of syphilis in which the syphilis spirochete enters the outer and middle layers of the aorta and causes aortitis, resulting in aortic aneurysms, aortic valve insufficiency, and coronary artery stenosis. Patients with these lesions should go to the hospital for syphilis spirochete serologic test and non-syphilis spirochete serologic test, etc. to clarify the cause of the disease. Commonly used syphilis spirochete serologic tests include syphilis spirochete particle agglutination test, fluorescent spirochete antibody uptake test, and syphilis spirochete enzyme-linked immunosorbent assay, etc., while commonly used non-syphilis spirochete serologic tests include RPR ring card test and TRUST toluidine red unheated serologic test, etc.. It is recommended that patients, if diagnosed, should maintain an optimistic attitude and actively cooperate with doctors for treatment.